Effects of carcinogenic versus non-carcinogenic AHR-active PAHs and their mixtures: lessons from ecological relevance.
نویسندگان
چکیده
Polycyclic aromatic hydrocarbons (PAHs) are priority environmental mutagens and carcinogens that occur in the aquatic environment as mixtures rather than the individual compounds for which guidelines are issued. The present work aimed at understanding the interaction effects between carcinogenic and non-carcinogenic PAHs in a model marine fish (Dicentrarchus labrax) in realistic scenarios. Laboratory assays under ecologically-relevant parameters were conducted for 28 days with sediments spiked with low-moderate concentrations (250-800ngg(-1)) of two model PAHs, phenanthrene (non-carcinogenic) and benzo[b]fluoranthene (carcinogenic to experimental animals). Both PAHs induced hepatic histopathological changes that indicate metabolic failure and inflammation, especially in animals exposed to mixtures. Phenanthrene elicited biochemical changes better related to oxidative stress (lipid peroxidation, glutathione and glutathione S-transferase activity) and CYP function, whereas B[b]F disrupted metabolic responses and defences to toxicological challenge. Conversely, mixed PAHs yielded lesions and responses that, altogether, are compatible with the AHR dependent pathway (the basis of PAH mutagenicity), potentially generating supra-additive effects. Nonetheless, the low, ecologically-relevant, concentrations of PAHs diluted dose and time-response relations. Overall, although seemingly predicting the risk of individual PAHs, environmental guidelines may not apply to mixtures by underestimating adverse effects, which calls for a redefinition of standards when determining the true risk of toxicants under realistic circumstances.
منابع مشابه
Ecological Risk Assessment and Source identification of PAHs by PMF model in petroleum contaminated soils; West of Kermanshah province
We collected soil samples at 23 sites from the petroleum contaminated soils (PC) in the west of Kermanshah province to investigate the sources and ecological risk of polycyclic aromatic hydrocarbons (PAHs). In this study, source apportionment has been carried out using Positive Matrix Factorization (PMF).The total PAHs concentration, have a mean value of 92.79 mg/kg, ranging from 7.37 to 609.67...
متن کاملAssessment of carcinogenic and non-carcinogenic hazards of heavy metals in surface soils of Bandar Mahshahr industrial zone in 1398
Background: Non-biodegradation in nature and the creation of adverse health effects in humans is important features of heavy metals. The main purpose of this study was to determine the carcinogenic and non-carcinogenic risks of heavy metals As, Cd, Cu, Cr, Pb, Ni, V, and Zn in the soils of industrial areas of Mahshahr port for adults and children. Methods: To study the environmental effects of ...
متن کاملDetermination of pollution level, carcinogenic and non-carcinogenic risks of heavy metals of falling dust in industrial areas (case study: Ardakan county industries)
Background and Objective: Non-biodegradation in nature and creation of adverse health effects in humans is important features of heavy metals. The main objective of this study was to determine the level of contamination, carcinogenic and non-carcinogenic risks of falling dust containing heavy metals on residents around the industrial areas of Ardakan. Another objective was to identify potential...
متن کاملPolycyclic Aromatic Hydrocarbons in the Dagang Oilfield (China): Distribution, Sources, and Risk Assessment
The levels of 16 polycyclic aromatic hydrocarbons (PAHs) were investigated in 27 upper layer (0-25 cm) soil samples collected from the Dagang Oilfield (China) in April 2013 to estimate their distribution, possible sources, and potential risks posed. The total concentrations of PAHs (∑PAHs) varied between 103.6 µg·kg(-1) and 5872 µg·kg(-1), with a mean concentration of 919.8 µg·kg(-1); increased...
متن کاملHuman Health and Ecological Risk Assessment of 16 Polycyclic Aromatic Hydrocarbons in Drinking Source Water from a Large Mixed-Use Reservoir.
Reservoirs play an important role in living water supply and irrigation of farmlands, thus the water quality is closely related to public health. However, studies regarding human health and ecological risk assessment of polycyclic aromatic hydrocarbons (PAHs) in the waters of reservoirs are very few. In this study, Shitou Koumen Reservoir which supplies drinking water to 8 million people was in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Environmental research
دوره 138 شماره
صفحات -
تاریخ انتشار 2015